Module 1 - GAP Theory
Module 2 - GAP Practice

4.2 Predictive tests

1st trimester – low PAPP-A, low beta-hCG 
2nd trimester – high AFP, hCG or inhibin A

  • These biomarkers are associated with an increased risk of placenta-related diseases such as pre-eclampsia and early onset fetal growth restriction. However their usefulness has not yet been established for everyday clinical application 9.
  • The lack of predictors of late onset FGR makes longitudinal surveillance of growth throughout pregnancy still the key method for assessment. 


9. Figueras F, Gardosi J. Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management. Am J Obstet Gynecol. 2011; 204(4):288-300. doi: 10.1016/j.ajog.2010.08.055